Ollie Hassell-Collins will make his England debut at left wing, Max Malins returns to the side at right wing and Freddie Steward is named at full back.

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Owen Farrell captains the side from inside centre and is joined in the midfield by Joe Marchant. Marcus Smith is at fly-half with Jack van Poortvliet at scrum half.

The front row is made up of vice-captain Ellis Genge and Kyle Sinckler with Jamie George at hooker. Maro Itoje and Ollie Chessum start at lock, while Ben Curry makes his second appearance for England at open-side flanker. Lewis Ludlam and Alex Dombrandt complete the back row.

Jack Walker is in line to make his England debut after being named as a substitute, Anthony Watson could make a first England appearance since March 2021, and if Dan Cole comes off the bench he will earn a 96th Test cap.

Mako Vunipola, Nick Isiekwe, Ben Earl, Ben Youngs and Ollie Lawrence make up the remaining replacements. 

"There are few fixtures in the rugby calendar that excite both players and supporters alike more than the annual Six Nations meeting of the Auld enemy as they battle for the honour of lifting the Calcutta Cup," said Borthwick.

"Another packed Twickenham will witness the start of the next chapter of English rugby in one of the most keenly contested tournaments in the world. There is no doubt this England team shares the supporters’ sense of eager anticipation. 

"To a man, the players are determined to play with the commitment, fight and desire that is at the very heart of representing England, the sort of passion that our tremendous supporters rightly expect."