There are four changes to the starting XV who defeated Italy in round four, with Luke Cowan-Dickie, Marcus Smith, Tom Roebuck, and Ben Curry all included.  

Cowan-Dickie starts at hooker, alongside Ellis Genge and Will Stuart, who is set to earn his 50th cap. In the back row, Tom Curry starts at blind-side flanker, with twin brother Ben at open-side, and Ben Earl at No.8.

Elliot Daly shifts to the left wing, with Roebuck on the right to make his first start of the Championship, and Marcus Smith starts at full back, while Tommy Freeman moves to outside centre.  

20-year-old Henry Pollock is set to earn his first senior England men’s cap from the bench, with George Ford also included on a 6-2 split replacements bench.

“We're excited to face Wales at the Principality Stadium this weekend, one of the most iconic venues in rugby,” said Borthwick. “The atmosphere will be electric, and we know we’ll need to be at our very best to get the result we’re aiming for.

"Reaching 50 caps is a well-deserved milestone for Will and a testament to the hard work he’s shown throughout his career. We’re excited to see him reach this landmark on Saturday and look forward to seeing him continue delivering performances at the highest level."