There are three changes to the starting XV that defeated Scotland, with Fraser Dingwall, Elliot Daly, and Jamie George all included.

George will win his 100th England cap, having made his debut in 2015 against France. Another 6-2 split bench - changes to it from Round 3 see Luke Cowan-Dickie, Marcus Smith and Jack van Poortvliet included. 

“England versus Italy is always an exciting fixture to be part of,” said Borthwick. “Playing in front of our home supporters at Allianz Stadium is something we’re really looking forward to, and we’re sure it will be a fantastic game of rugby.”

“Reaching 100 caps is a wonderful achievement that reflects Jamie's talent, dedication and hard work. He has consistently given his all while wearing an England shirt and the team couldn’t be prouder of his incredible milestone."